Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability
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چکیده
منابع مشابه
Evaluation of CD133 and CD56/NCAM expression in Wilms tumor and their association with prognostic factors
Objective(s): To validate certain markers for cancer stem cell populations and their clinical importance in Wilms tumor (WT)Materials and Methods: Immunohistochemical study for CD133 and CD56/NCAM was performed on forty-six cases of WT that were diagnosed between 1999 and 2015, and the association of these markers with survival and progn...
متن کاملtumor microsatellite instability and clinicopathologic features in iranian colorectal cancer patients at risk for lynch syndrome
background: microsatellite instability (msi) is a mutational signature that is the hallmark of lynch syndrome, and msi testing is a cost-effective method to screen the disease. since there is no enough data about msi status and associated clinicopathologic features of hereditary nonpolyposis colorectal cancer (hnpcc) in iran, our study is a new trial to describe them in center of iran (isfahan)...
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PURPOSE Although the decreased expression of p27(kip-1), a cyclin-dependent kinase inhibitor, has been correlated with advanced tumor stage and short survival of patients with colorectal adenocarcinomas (CRCs), its prognostic value based on the tumor site, tumor stage, and patient ethnicity was not assessed. Therefore, in this study, we investigated whether the prognostic value of p27(kip-1) ex...
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Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was deter...
متن کاملMSIsensor: microsatellite instability detection using paired tumor-normal sequence data
MOTIVATION Microsatellite instability (MSI) is an important indicator of larger genome instability and has been linked to many genetic diseases, including Lynch syndrome. MSI status is also an independent prognostic factor for favorable survival in multiple cancer types, such as colorectal and endometrial. It also informs the choice of chemotherapeutic agents. However, the current PCR-electroph...
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ژورنال
عنوان ژورنال: Virchows Archiv
سال: 2007
ISSN: 0945-6317,1432-2307
DOI: 10.1007/s00428-007-0444-1